Amyloidosis disorder (am-uh-loi-DO-sis) is a rare condition that arises when irregular proteins, or amyloids, build up in the organs and interfere with their normal function.
Amyloid is not commonly present in the body, but it may be produced from a variety of different protein forms. Organs that may be affected include the heart, kidney, liver, spleen, nervous system, and digestive tract.
Some types of amyloidosis are linked with other disorders. These styles may change with the treatment of the underlying disease. Any varieties of amyloidosis can contribute to life-threatening failure of the heart.
Treatments may include chemotherapy similar to those used to fight cancer. Your doctor may prescribe drugs to reduce the development and control of amyloid symptoms. Any people may benefit from organ or stem cell transplantation.
You do not encounter signs and symptoms of amyloidosis until the disease is advanced. When signs and symptoms are apparent, they depend on which of the organs is damaged.
Signs and signs of amyloidosis disorder can include:
Your bone marrow usually produces blood cells that your body uses to transport oxygen to your tissues, combat bacteria, and support your blood clot.
In one form of amyloidosis disorder, white blood cells (plasma cells) that battle infection in the bone marrow contain an irregular protein called amyloid. This protein folds and clumps, and it’s harder for the body to break down.
In addition, amyloidosis is caused by the build-up of amyloid in your organs. How the amyloid gets there depends on what sort of disease you have:
Light chain (AL) amyloidosis: the most common form of amyloidosis. It occurs when irregular amyloid proteins called light chains build up in organs such as the heart, kidneys, liver, and skin. This form was used to be called primary amyloidosis.
Autoimmune (AA) amyloidosis disorder: you may have this form of illness, such as tuberculosis, or a condition that induces inflammation, such as rheumatoid arthritis or inflammatory bowel disease. Around half of those with AA amyloidosis have rheumatoid arthritis. AA amyloidosis mostly affects the kidneys. It can even damage your intestines, your kidneys, or your heart. This form was used to be called secondary amyloidosis.
Dialysis-related amyloidosis: this form affects patients who have been on dialysis for a long time due to kidney complications. The amyloid is deposited in the joints and tendons, causing inflammation and stiffness.
Hereditary (family) amyloidosis: this rare type is caused by a mutation in the family genome. Hereditary amyloidosis can affect the nerves, heart, liver and kidneys.
Senile amyloidosis disorder: this form affects the heart of older men.
While anyone may get amyloidosis, certain things increase the chance.
This include the following:
The possible symptoms of amyloidosis disorder depend on which amyloid deposits impact the organs. Amyloidosis can do significant damage to the body:
Core, Amyloid inhibits the capacity of your heart to fill the bloodstream with blood between heartbeats. Less blood is pumped with every pulse, and you can feel shortness of breath. If the heart’s electrical system is compromised by amyloidosis disorder, the heart’s rhythm can be disrupted. Amyloid-related heart attacks can be life-threatening.
Kidneys. Amyloid will damage the kidney filtering system, allowing the protein to leak out of your blood to your urine. The power of the kidneys to extract waste materials from your body is decreased, which can ultimately lead to kidney failure and the need for dialysis.
Nervous system, You may experience discomfort, numbness or tingling in your fingertips or numbness, loss of feeling or burning sensation in your toes or soles of your legs. If amyloid activates the nerves that regulate the bowel function, there may be cycles of alternating constipation and diarrhea. If it affects the nerves that regulate the blood pressure, you can feel faint after getting up too fast.
You will be asked by your doctor about your symptoms and medical history. As best as you can, it’s crucial to notify the doctor because the effects of amyloidosis Disorder can be close to those of other diseases. Misdiagnosis is prevalent.
The following tests can be used by your doctor to help make a diagnosis:
Your doctor will figure out which type you have if a diagnosis is made. With tests like immunochemical staining and protein electrophoresis, this can be done.
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